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| juvenile primary lateral sclerosis ： ウィキペディア英語版 |
juvenile primary lateral sclerosis
Juvenile primary lateral sclerosis (JPLS) '', also known as primary lateral sclerois (PLSJ),'' is a rare genetic disorder, with a small number of reported cases, characterized by progressive weakness and stiffness of muscles in the arms, legs, and face. The disorder damages motor neurons, which are specialized nerve cells in the brain and spinal cord that control muscle movement.
==Symptoms and progression==
Symptoms of JPLS begin in early childhood and progress over a period of 15 to 20 years. Early symptoms include clumsiness, muscle spasms, weakness and stiffness in the legs, and difficulty with balance. As symptoms progress, they become more serious and include weakness and stiffness in the arms and hands, slurred speech, drooling, difficulty swallowing, and an inability to walk.
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